Open AccessTaxifolin, Extracted from Waste Larix olgensis Roots, Attenuates CCl4-Induced Liver Fibrosis by Regulating the PI3K/AKT/mTOR and TGF-β1/Smads Signaling Pathways
Author(s) -
Xinglong Liu,
Wencong Liu,
Chuanbo Ding,
Yingchun Zhao,
Xueyan Chen,
Ling Dong,
Yajuan Zheng,
Zhiqiang Cheng
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s281369
Subject(s) - taxifolin , pi3k/akt/mtor pathway , sirius red , chemistry , protein kinase b , pharmacology , hepatocyte , hepatic stellate cell , fibrosis , apoptosis , biochemistry , endocrinology , antioxidant , medicine , quercetin , in vitro
Taxifolin is a kind of dihydroflavone and is usually used as a food additive and health food for its antioxidant, anti-inflammatory, and anti-tumor activities. The purpose of this research is to probe into the hepatoprotective activity and the molecular mechanism of taxifolin.