Open Access<p>Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling</p>
Author(s) -
Qicen Yao,
Qingchao Wu,
Xiayu Xu,
Yixi Xing,
Liang Jin,
Qianqi Lin,
Meiqiong Huang,
YiLing Chen,
Bo Lin,
Wei-Fei Chen
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s281209
Subject(s) - kegg , resveratrol , pi3k/akt/mtor pathway , sirtuin 1 , inflammation , signal transduction , sirtuin , cancer research , fibrosis , biology , microbiology and biotechnology , pharmacology , immunology , transcriptome , medicine , gene , downregulation and upregulation , gene expression , biochemistry , acetylation
Resveratrol (Res) is a natural polyphenolic compound found in several plants and reported as a promising biological molecule with effective anti-fibrosis and anti-inflammatory activities. However, the underlying mechanism of Res on systemic sclerosis (SSc) remains unclear. In the study, we identified the key cellular signaling pathways involved in the Res regulatory process on SSc.