Open AccessDihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy
Author(s) -
Xiaoyuan Wang,
Wuqi Song,
Fengmin Zhang,
Renping Huang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s280322
Subject(s) - autophagy , transforming growth factor , fibrosis , cancer research , mortise and tenon , dihydroartemisinin , fibroblast , pharmacology , microbiology and biotechnology , chemistry , medicine , biology , pathology , apoptosis , biochemistry , engineering , structural engineering , artemisinin , malaria , plasmodium falciparum , in vitro
The formation of hypertrophic scars (HS) can result in the failure of glaucoma surgery, and fibrosis is known to be closely associated with the progression of HS. Dihydroartemisinin (DHA) has been reported to inhibit the progression of fibrosis; however, whether DHA can alleviate the formation of HS remains unclear.