Open Access<p>QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia</p>
Author(s) -
Anita Kovács,
Nikolett Kis,
Mária Budai-Szűcs,
Attila Gácsi,
Erzsébet Csányi,
Ildikó Csóka,
Szilvia Berkó
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s279727
Subject(s) - permeation , critical quality attributes , silicone , materials science , chromatography , spreadability , factorial experiment , pig skin , biomedical engineering , chemistry , chemical engineering , composite material , medicine , computer science , membrane , particle size , biochemistry , food science , machine learning , engineering
The aim of our research work was to develop dermally applicable, lidocaine hydrochloride (LID-HCl)-containing semisolid in situ film-forming systems (FFSs) using the Quality by Design (QbD) approach to increase drug permeation into the skin.