Open Access<p>Impact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study</p>
Author(s) -
Hongliang Zhu,
Aolin Ren,
Kang Zhou,
Qiuchong Chen,
Mengjun Zhang,
Jindong Liu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s278342
Subject(s) - medicine , dexmedetomidine , perioperative , acute kidney injury , anesthesia , retrospective cohort study , incidence (geometry) , renal replacement therapy , bradycardia , propensity score matching , postoperative nausea and vomiting , surgery , adverse effect , nausea , sedation , heart rate , blood pressure , physics , optics
Postoperative acute kidney injury (AKI) is a frequent complication in elderly patients that increases morbidity and mortality. Approximately 1.7 million people die from AKI worldwide every year. Dexmedetomidine (Dex) is often used as an adjunct to multimodal analgesia. Our study investigated whether Dex could safely decrease the incidence of AKI in elderly patients undergoing major joint replacement.