Open AccessPaeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis
Author(s) -
Yanhong Wang,
Qian Wang,
Xibei Li,
Gongwen Luo,
Mou Shen,
Jianqiang Shi,
Xueliang Wang,
Lu Tang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s278002
Subject(s) - catenin , breast cancer , tamoxifen , microrna , cyclin d1 , cancer research , medicine , cancer , oncology , bioinformatics , chemistry , biology , signal transduction , wnt signaling pathway , microbiology and biotechnology , gene , cell cycle , biochemistry
Paeoniflorin (Pae) possesses anti-tumor activity in various malignancies. However, it is unclear whether Pae plays a sensitizer role in breast cancer (BC) and the molecular mechanisms involved in this process. Our oligonucleotide microarray revealed that microRNA (miR)-15b is the most significantly downregulated miRNA in MCF-7/4-hydroxytamoxifen (4-OHT) cells treated with Pae. This paper summarized the relevance of Pae in BC cell endocrine resistance to tamoxifen (Tam) and the molecular mechanisms involved miR-15b expression.