Open Access<p>Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model</p>
Author(s) -
Yu–Faye Chao,
Ping Li,
Yanxiu Wang,
Kaigang Zhang,
Zuncheng Zheng,
LiJung Liang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s276424
Subject(s) - neuropathic pain , medicine , p38 mitogen activated protein kinases , pharmacology , neuroinflammation , mapk/erk pathway , neuroprotection , anesthesia , tumor necrosis factor alpha , inflammation , signal transduction , chemistry , biochemistry
Neuropathic pain seriously affects life quality, and it is urgent to develop novel drugs with high efficacy and few side effects. Sanguinarine (SG) is a natural plant medicine with anti-inflammatory and neuroprotection effects. This study aimed to investigate the effect of SG on chronic constriction injury (CCI)-induced neuropathic pain.