Open Access<p>Activation of PI3K/Akt/HIF-1α Signaling is Involved in Lung Protection of Dexmedetomidine in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Pilot Study</p>
Author(s) -
Lijun Zhu,
Yang Zhang,
Zhenfeng Zhang,
Xiahao Ding,
Chanjuan Gong,
Yanning Qian
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s276005
Subject(s) - medicine , dexmedetomidine , lung , anesthesia , hypoxia (environmental) , cardiothoracic surgery , agonist , surgery , receptor , chemistry , organic chemistry , oxygen , sedation
Lung resection and one lung ventilation (OLV) during video-assisted thoracoscopic surgery (VATS) may lead to acute lung injury. Dexmedetomidine (DEX), a highly selective α 2 adrenergic receptor agonist, improves arterial oxygenation in adult patients undergoing thoracic surgery. The aim of this pilot study was to explore possible mechanism related to lung protection of DEX in patients undergoing VATS.