Open Access<p>Ulinastatin Inhibits the Proliferation, Invasion and Phenotypic Switching of PDGF-BB-Induced VSMCs via Akt/eNOS/NO/cGMP Signaling Pathway</p>
Author(s) -
Cheng Huang,
Weihui Huang,
Rui Wang,
Yongli He
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s275488
Subject(s) - enos , protein kinase b , phenotypic switching , platelet derived growth factor receptor , signal transduction , cell growth , pi3k/akt/mtor pathway , inflammation , western blot , cancer research , soluble guanylyl cyclase , vascular smooth muscle , microbiology and biotechnology , biology , pharmacology , immunology , chemistry , medicine , endocrinology , nitric oxide , nitric oxide synthase , growth factor , biochemistry , receptor , smooth muscle , gene , guanylate cyclase
Atherosclerosis is a chronic inflammatory disease responsible for thrombosis, blood supply disorders, myocardial infarction and strokes, eventually leading to increased deaths and reduced quality of life. As inflammation plays a vital role in the development of this disease, the present study aims to investigate whether urinary trypsin inhibitor (UTI) with anti-inflammatory property can inhibit the proliferation, invasion and phenotypic switching of PDGF-BB-induced vascular smooth muscle cells (VSMCs) and probe its potential mechanism.