Open Access<p>Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation</p>
Author(s) -
Shubin Wang,
Binhui Lin,
Wei Liu,
Guojun Wei,
Zongguang Li,
Naichun Yu,
Xiang Xue,
Guangrong Ji
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s275148
Subject(s) - acacetin , apoptosis , flow cytometry , annexin , chemistry , microbiology and biotechnology , cell growth , viability assay , cancer research , biology , biochemistry , flavonoid , antioxidant , apigenin
The long-term survival rate of osteosarcoma, which is the most common type of primary malignant bone tumor, has stagnated in past decades. Acacetin is a natural flavonoid compound that has antioxidative and anti-inflammatory effects and exhibits extensive therapeutic effects on various cancers. In this study, the anticancer potential of acacetin and the underlying molecular mechanisms were examined in human osteosarcoma cells (SJSA and HOS).