Open AccessPTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells
Author(s) -
Gaoliang Yan,
Renhua Sun,
Zhongpu Chen,
Xiaodong Pan,
Zulong Sheng,
Chengchun Tang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s275000
Subject(s) - gene knockdown , polypyrimidine tract binding protein , pulmonary hypertension , phenotype , integrin linked kinase , pulmonary artery , cancer research , hypoxia (environmental) , western blot , biology , gene , microbiology and biotechnology , kinase , protein kinase a , chemistry , messenger rna , medicine , rna binding protein , genetics , cyclin dependent kinase 2 , organic chemistry , oxygen
Pulmonary hypertension (PH) is a pathological process mainly characterized by the progressive increase in pulmonary vascular resistance. The degradation of pulmonary artery smooth muscle cells (PASMCs) from contractile/differentiated phenotype to synthetic/dedifferentiated phenotype is a key factor for hypoxic pulmonary hypertension.