Open Access<p>Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo</p>
Author(s) -
Hao Wang,
Zengxin Jiang,
Zhiying Pang,
Tianyao Zhou,
Yutong Gu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s274812
Subject(s) - acacetin , aggrecan , mmp3 , intervertebral disc , chemistry , microbiology and biotechnology , in vivo , extracellular matrix , biochemistry , antioxidant , medicine , pathology , anatomy , biology , osteoarthritis , apigenin , gene expression , flavonoid , alternative medicine , gene , articular cartilage
Intervertebral disc degeneration (IDD) is one of the most prevalent musculoskeletal disorders. The nucleus pulposus is the major component of the intervertebral disc, and nucleus pulposus cells (NPCs) play a significant role in the normal functioning of the intervertebral disc. Reactive oxygen species (ROS) generation, inflammation and extracellular matrix degradation in NPCs contribute to the degeneration of intervertebral discs. Acacetin is a drug that exerts antioxidant and anti-inflammatory effects on many types of cells. However, whether acacetin can relieve the degeneration of NPCs remains unknown.