Open AccessMetabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity
Author(s) -
Kai Wang,
Jinqiu Rao,
Tingting Zhang,
Qing Gao,
Jichao Zhang,
Chenxi Guang,
Lei Ding,
Feng Qiu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s274627
Subject(s) - coptis chinensis , glutathione , pharmacology , chemistry , biochemistry , cysteine , alkaloid , biology , medicine , traditional chinese medicine , enzyme , stereochemistry , pathology , alternative medicine
Berberrubine (BRB), an isoquinoline alkaloid, is a major constituent of medicinal plants Coptis chinensis Franch or Phellodendron chinense Schneid. BRB exhibits various pharmacological activities, whereas exposure to BRB may cause toxicity in experimental animals.