Open Access<p>Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy</p>
Author(s) -
Zhichao Zheng,
Wei Zhu,
Lei Lei,
Xue-Qi Liu,
Yuangang Wu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s274256
Subject(s) - wogonin , diabetic nephropathy , medicine , inflammation , ctgf , fibrosis , endocrinology , diabetes mellitus , pharmacology , pathology , growth factor , scutellaria baicalensis , receptor , alternative medicine , traditional chinese medicine
Diabetic nephropathy (DN) has become an increasing threat to health, and inflammation and fibrosis play important roles in its progression. Wogonin, a flavonoid, has been proven to suppress inflammation and fibrosis in various diseases, including acute kidney injury. This study aimed at investigating the effect of wogonin on diabetes-induced renal inflammation and fibrosis.