Open Access<p>Stoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells</p>
Author(s) -
Jamal Moideen Muthu Mohamed,
Ali Alqahtani,
Fazil Ahmad,
Krishnaraju Venkatesan,
K. Kalpana
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s273322
Subject(s) - solubility , dissolution , poloxamer , chemistry , dissolution testing , thermogravimetric analysis , nuclear chemistry , dynamic light scattering , curcumin , poloxamer 407 , chromatography , materials science , nanoparticle , nanotechnology , organic chemistry , biochemistry , copolymer , biopharmaceutics classification system , polymer
Colorectal cancer (CRC) is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women. Curcumin (CMN) is obtained from a natural source and has no toxicity, even at high doses (8,000 mg/kg body weight in 24 hours) and was determined to have anticancer potency on several kinds of carcinoma. However, its medical applications were limited because of its low solubility and poor bioavailability.