Open AccessAlprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition
Author(s) -
Zhenbai Qin,
Biao Kong,
Jing Zheng,
Xiantao Wang,
Lang Li
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - Uncategorized
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s272877
Subject(s) - apoptosis , tunel assay , malondialdehyde , medicine , cardiac function curve , troponin i , pharmacology , oxidative stress , ventricle , endocrinology , chemistry , myocardial infarction , immunohistochemistry , heart failure , biochemistry
Coronary microembolization (CME) results in progressive contractile dysfunction associated with cardiomyocyte apoptosis. Alprostadil injection improves microcirculation, which is effective in treating various cardiovascular disorders. However, the therapeutic effects of alprostadil in CME-induced myocardia injury remain unknown. Therefore, we evaluated the effects of alprostadil injection on cardiac protection in a rat model of CME and explored the underlying mechanisms.