Open AccessMagnesium Isoglycyrrhizinate Induces an Inhibitory Effect on Progression and Epithelial–Mesenchymal Transition of Laryngeal Cancer via the NF-κB/Twist Signaling
Author(s) -
Jiarui Zhang,
Rui Zhao,
Deguo Xing,
Jing Cao,
Yan Guo,
Liang Li,
Yanan Sun,
Linli Tian,
Ming Liu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s272323
Subject(s) - epithelial–mesenchymal transition , apoptosis , cancer , cancer research , cancer cell , mtt assay , in vivo , cell growth , western blot , medicine , pathology , chemistry , biology , metastasis , biochemistry , microbiology and biotechnology , gene
Magnesium isoglycyrrhizinate (MI) was extracted from roots of the plant Glycyrrhiza glabra, which displays multiple pharmacological activities such as anti-inflammation, anti-apoptosis, and anti-tumor. Here, we aimed to investigate the effect of MI on the progression and epithelial-mesenchymal transition (EMT) of laryngeal cancer.