Open Access<p>Synthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials</p>
Author(s) -
Ashraf Atef Hatamleh,
Dunia A. Al Farraj,
Sarah Salah Al-Saif,
SathishKumar Chidambaram,
Radhakrishnan Surendrakumar,
Akbar Idhayadhulla
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s270896
Subject(s) - tetrazole , chemistry , hela , mannich base , docking (animal) , antimicrobial , autodock , clotrimazole , enterococcus faecalis , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , biology , escherichia coli , microbiology and biotechnology , in silico , antifungal , medicine , nursing , gene , cell
A new series of tetrazole derivatives, which are renowned antimicrobials possessing a five-membered aromatic heterocyclic group, are synthesized herein and subjected to antimicrobial and cytotoxicity screening.