Open Access<p>EGCG Upregulates UCP<sub>3</sub> Levels to Protect MIN<sub>6</sub> Pancreatic Islet Cells from Interleukin-1β-Induced Apoptosis</p>
Author(s) -
Xu Jia,
Ziren Luo,
Ying Gao,
Hua Liu,
Xinghai Liu,
Wenli Mai,
Hong Liu,
Qingyin Zheng
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s270345
Subject(s) - ucp3 , apoptosis , flow cytometry , viability assay , microbiology and biotechnology , uncoupling protein , chemistry , biology , endocrinology , biochemistry , adipose tissue , brown adipose tissue
The protective effects of epigallocatechin gallate (EGCG) on interleukin-1β (IL-1β)-induced apoptosis were investigated in murine MIN 6 pancreatic β-cells. The role of uncoupling protein-3 (UCP 3 ) signaling in this process was also explored.