Open Access<p>[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT<sub>3</sub> Receptor System in Rats</p>
Author(s) -
Qianqian Cheng,
Xiaodi Feng,
Qi Meng,
Yaqi Li,
Siqi Chen,
Guoen Wang,
Ke Nie
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s270185
Subject(s) - cisplatin , ondansetron , pharmacology , saline , 5 ht receptor , chemistry , 5 ht3 receptor , serotonin , receptor , medicine , anesthesia , chemotherapy , biochemistry , nausea
[6]-gingerol is a bioactive compound extracted from ginger, a traditional anti-emetic herb in Chinese medicine. Previous studies have demonstrated that [6]-gingerol can ameliorate chemotherapy-induced pica in rats, although the underlying mechanism has not been elucidated. This study is designed to investigate [6]-gingerol's antiemetic mechanism focusing on the 5-hydroxytryptamine (serotonin, 5-HT) system by evaluating the synthesis, metabolism and reuptake of 5-HT, as well as the mechanism of 5-hydroxytryptamine type 3 receptor (5-HT 3 receptor), in a cisplatin-induced pica model of rats.