Open Access<p>Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels</p>
Author(s) -
Naeem Ur Rehman,
Muzaffar Abbas,
Mariya alRashida,
Ahmed Tokhi,
Muhammad Awais Arshid,
Muhammad Sona Khan,
Iftikhar Ahmad,
Khalid Rauf
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s270025
Subject(s) - nicotine , pharmacology , saline , dopaminergic , sensitization , intraperitoneal injection , chemistry , medicine , dopamine , anesthesia , immunology
Behavioral sensitization is a phenomenon that develops from intermittent exposure to nicotine and other psychostimulants, which often leads to heightened locomotor activity and then relapse. Sulfonamides that act as carbonic anhydrase inhibitors have a documented role in enhancing dopaminergic tone and normalizing neuroplasticity by stabilizing glutamate release.