Open AccessCapsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
Author(s) -
Maojian Chen,
Chanchan Xiao,
Wei Jiang,
Weiping Yang,
Qinghong Qin,
Qian Tan,
Bin Lian,
Zheng Liang,
Changyuan Wei
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s269901
Subject(s) - survivin , apoptosis , oncogene , cancer research , gene silencing , carcinogenesis , breast cancer , cell growth , small interfering rna , cancer , capsaicin , biology , microbiology and biotechnology , transfection , chemistry , cell cycle , cell culture , gene , receptor , biochemistry , genetics
As a natural compound extracted from a variety of hot peppers, capsaicin has drawn increasing attention to its anti-cancer effects against multiple human cancers including breast cancer. FBI-1 is a major proto-oncogene negatively regulating the transcription of many tumor suppressor genes, and plays a vital role in tumorigenesis and progression. However, whether FBI-1 is involved in capsaicin-induced breast cancer suppression has yet to be ascertained. This study aimed to investigate the effects of capsaicin on proliferation and apoptosis and its association with FBI-1 expression in breast cancer.