Open Access<p>The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice</p>
Author(s) -
Liang-Jian Hong,
Aijun Chen,
FengZeng Li,
Kejun Chen,
Sheng Fang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s269725
Subject(s) - protein kinase b , pi3k/akt/mtor pathway , heat shock protein , signal transduction , flow cytometry , chemistry , hsp90 , phosphorylation , immune system , immunology , microbiology and biotechnology , cancer research , endocrinology , biology , medicine , biochemistry , gene
To explore the molecular mechanism of 17-AAG in the treatment of systemic lupus erythematosus (SLE), and the effects of the heat shock protein 90 (HSP90) inhibitor 17-AAG on the activation and proliferation of lymphocytes and the AKT/GSK3β signaling pathway in MRL/lpr mice were detected.