Open Access<p>Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway</p>
Author(s) -
Cancan Huang,
Chaotao Zhang,
Panpan Yang,
Rui Chao,
Ziqi Yue,
Congshan Li,
Jie Guo,
Minqi Li
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s269223
Subject(s) - pyroptosis , inflammasome , chemistry , pharmacology , lipopolysaccharide , viability assay , intracellular , flow cytometry , caspase 1 , microbiology and biotechnology , immunology , apoptosis , medicine , biochemistry , biology , receptor
Periodontitis is a major chronic oral disease that is accelerated by activation of the NLRP3 inflammasome and the resulting pyroptosis. According to recent studies, active vitamin D and its analogs have been reported to have great anti-inflammatory effects. However, the anti-inflammatory mechanism of a newly found vitamin D analog, eldecalcitol (ED-71), is still unclear. This study investigates whether ED-71 could protect human gingival fibroblasts (HGFs) from LPS-induced pyroptosis and, if so, determine its underlying mechanism.