Open Access<p>The Impact of Icariside II on Human Prostate Cancer Cell Proliferation, Mobility, and Autophagy via PI3K-AKT-mTOR Signaling Pathway</p>
Author(s) -
Shuang Li,
Yunlu Zhan,
Yingwei Xie,
Yonghui Wang,
Yuexin Liu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s268524
Subject(s) - pi3k/akt/mtor pathway , autophagy , protein kinase b , cancer research , prostate cancer , cell growth , discovery and development of mtor inhibitors , signal transduction , medicine , chemistry , cancer , apoptosis , microbiology and biotechnology , biology , biochemistry
The flavonol glycoside icariside II (ICA II) has been shown to exhibit a range of anti-tumor properties. Herein, we evaluated the impact of ICA II on human prostate cancer cell proliferation, motility, and autophagy, and we further evaluated the molecular mechanisms underlying these effects.