Open Access<p>Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells</p>
Author(s) -
Hongfang Li,
Yunyan Tang,
Yan Wang,
Weipeng Wei,
Chengchen Yin,
Fushang Tang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s268358
Subject(s) - cyp1a2 , chemistry , cyp2d6 , pharmacology , microbiology and biotechnology , biology , biochemistry , cytochrome p450 , metabolism
Bupleurum is one of the most important traditional Chinese medicines and an ingredient in many compound preparations. It is widely used together with other drugs in clinical practice, and thus there is great potential for drug-drug interactions. Saikosaponin D (SsD) is a major bioactive triterpenoid saponin extracted from Bupleurum with anti-inflammatory, anticancer, antioxidative, and antihepatic fibrosis effects. Effects of the main components of Bupleurum on cytochromes P450 (CYPs) need to be clarified in the clinical application of combination therapies of formulations containing SsD or Bupleurum .