Open AccessPhyscion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway
Author(s) -
Xiaobo Dong,
Lei Wang,
Guanbin Song,
ChunFang Xu,
Wenxin Wang,
Jiaqi Chen,
Gesheng Wang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s267856
Subject(s) - neuroprotection , apoptosis , pharmacology , ischemia , western blot , tlr4 , reperfusion injury , sh sy5y , oxidative stress , chemistry , flow cytometry , tumor necrosis factor alpha , neuroinflammation , medicine , inflammation , biology , signal transduction , biochemistry , immunology , cell culture , genetics , gene , neuroblastoma
Ischemic stroke (IS) is characterized by the rapid loss of brain function due to ischemia. Physcion has been found to have a neuroprotective effect against cerebral ischemia-reperfusion (I/R) injury. However, the mechanism by which physcion regulates cerebral I/R injury remains largely unknown.