Open Access<p>Resveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase</p>
Author(s) -
Liang Wang,
Qiushi Li,
Haibo Yan,
Guangjun Jiao,
Hongliang Wang,
Hai Chi,
Hongming Zhou,
Lu Chen,
Shan Yu,
Yunzhen Chen
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s266502
Subject(s) - resveratrol , chemistry , tfam , osteoblast , superoxide dismutase , sirtuin 1 , microbiology and biotechnology , viability assay , alkaline phosphatase , apoptosis , biology , biochemistry , mitochondrion , mitochondrial biogenesis , oxidative stress , downregulation and upregulation , in vitro , gene , enzyme
Glucocorticoids are used for the treatment of inflammatory diseases, but glucocorticoid treatment is associated with bone damage. Resveratrol is a phytoalexin found in many plants, and we investigated its protective role on dexamethasone-induced dysfunction in MC3T3-E1 cells and primary osteoblasts.