Open Access<p>Integrated Network Pharmacology Analysis and Experimental Validation to Reveal the Mechanism of Anti-Insulin Resistance Effects of <em>Moringa oleifera</em> Seeds</p>
Author(s) -
Qiong Huang,
Rong Liu,
Jing Liu,
Qi Huang,
Lei Shao,
Yueping Jiang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s265198
Subject(s) - insulin resistance , pharmacology , mechanism (biology) , glycosidic bond , moringa , mechanism of action , chemistry , computational biology , insulin , biochemistry , biology , traditional medicine , medicine , in vitro , microbiology and biotechnology , enzyme , philosophy , epistemology
Insulin resistance (IR) is one of the factors that results in metabolic syndrome, type 2 diabetes mellitus and different aspects of cardiovascular diseases. Moringa oleifera seeds (MOS), traditionally used as an antidiabetic food and traditional medicine in tropical Asia and Africa, have exhibited potential effects in improving IR. To systematically explore the pharmacological mechanism of the anti-IR effects of MOS, we adopted a network pharmacology approach at the molecular level.