Open Access<p>Formulation of Nanospanlastics as a Promising Approach for Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, in vitro Characterization, and ex vivo Permeation Study</p>
Author(s) -
Farid A. Badria,
Eman A. Mazyed
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s265167
Subject(s) - pulmonary surfactant , chemistry , zeta potential , differential scanning calorimetry , factorial experiment , bioavailability , permeation , fourier transform infrared spectroscopy , drug delivery , adme , boswellia serrata , lipophilicity , nuclear chemistry , stereochemistry , materials science , in vitro , nanotechnology , chemical engineering , mathematics , organic chemistry , pharmacology , membrane , biochemistry , nanoparticle , medicine , thermodynamics , alternative medicine , pathology , engineering , statistics , physics
The current study aimed to discuss the potential of nanospanlastics as a surfactant-based vesicular system for improving the topical delivery of 3-acetyl-11-keto-β-boswellic acid (AKBA). AKBA is a potent anti-inflammatory drug, but it has poor oral bioavailability due to its poor aqueous solubility. Moreover, the topical delivery of AKBA is difficult due to its high lipophilicity. To overcome these drawbacks, AKBA was formulated as deformable elastic nanovesicles and nanospanlastics, for improving its topical delivery.