Open AccessNew Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations
Author(s) -
Tivadar Bíró,
Alexandra Bocsik,
Bisera Jurišić Dukovski,
Ilona Gróf,
Jasmina Lovrić,
Ildikó Csóka,
Mária A. Deli,
Zoltán Aigner
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s264745
Subject(s) - benzalkonium chloride , ex vivo , eye drop , chemistry , pharmacology , cornea , in vivo , drug delivery , cyclodextrin , chromatography , in vitro , medicine , biochemistry , ophthalmology , organic chemistry , biology , microbiology and biotechnology
Optimal transcorneal penetration is necessary for ocular therapy; meanwhile, it is limited by the complex structure and defensive mechanisms of the eye. Antimicrobial stability of topical ophthalmic formulations is especially important. According to previous studies, the mostly used preservative, benzalkonium-chloride is irritative and toxic on corneal epithelial cells; therefore, novel non-toxic, antimicrobial agents are required. In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects.