Open Access<p>Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway</p>
Author(s) -
Hongfei Ke,
Dexiang Liu,
Tingting Li,
Xili Chu,
Danqing Xin,
Min Seok Han,
Shuanglian Wang,
Zhen Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s264684
Subject(s) - neuroprotection , microglia , protein kinase b , phagocytosis , hypoxia (environmental) , pharmacology , pi3k/akt/mtor pathway , apoptosis , ischemia , striatum , medicine , neuroscience , biology , chemistry , immunology , endocrinology , inflammation , biochemistry , oxygen , organic chemistry , dopamine
We have reported previously that hydrogen-rich saline (HS) plays a neuroprotective role in hypoxia-ischemia (HI) brain damage in newborn mice. However, the mechanisms for this neuroprotection resulting from HS remain unknown. In this study, we examined the potential for HS to exert effects upon microglial phagocytosis via involvement of the Akt signaling pathway as one of the neuroprotective mechanisms in response to neonatal HI.