Open Access<p>Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification</p>
Author(s) -
Limin Zhou,
Hongyan Wu,
Xiang Gao,
Xiaoyan Zheng,
Hang Chen,
Hailong Li,
Jinliang Peng,
Weichong Liang,
Wenxing Wang,
Zuo-Cheng Qiu,
Anjaneyulu Udduttula,
Kefeng Wu,
Lin Li,
Yuyu Liu,
Yanzhi Liu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s263787
Subject(s) - endochondral ossification , bone healing , nonunion , ossification , osteocalcin , cartilage , wound healing , chondrogenesis , chemistry , andrology , pathology , medicine , surgery , anatomy , biochemistry , alkaline phosphatase , enzyme
Nonunion is a major complication in fracture repair and remains a challenge in orthopaedics and trauma surgery. In this study, we aimed to evaluate the effectiveness of treatment of nonunion with a large radial defect using a bone-targeting liposome-encapsulated salvianic acid A (SAA-BTL)-incorporated collagen sponge and further elucidate whether the effects were closely related to histone deacetylase 3 (HDAC 3)-mediated endochondral ossification in nonunion healing process.