Open Access<p>Synthesis and Bioactivity of <em>N</em>-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent</p>
Author(s) -
A-Long Cui,
Wenfang Sun,
Zhaojin Zhong,
Jie Jin,
Si-tu Xue,
Shuo Wu,
Yuhuan Li,
Zhuorong Li
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s263701
Subject(s) - hepatitis b virus , lamivudine , virology , medicine , pharmacology , hepatitis b , in vivo , virus , biology , microbiology and biotechnology
Hepatitis B virus (HBV) is a global health concern that can cause acute and chronic liver diseases. Thus, there is an urgent need to research novel anti-HBV agents. Our previous reports show that N -phenylbenzamide derivatives exert broad-spectrum antiviral effects against HIV-1, HCV, and EV71 by increasing intracellular levels of APOBEC3G (A3G). As A3G is capable of inhibiting the replication of HBV, we screened the N -phenylbenzamide derivatives against HBV.