Open Access<p>Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury</p>
Author(s) -
Bo Yang,
Lie Zang,
Jingwen Cui,
Mingyuan Zhang,
Xue Ma,
Luqing Wei
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s262121
Subject(s) - oxidative stress , melatonin , neuroprotection , pharmacology , autophagy , stat3 , western blot , tunel assay , apoptosis , in vivo , ischemia , reperfusion injury , inflammation , stat protein , chemistry , biology , medicine , endocrinology , biochemistry , microbiology and biotechnology , gene
Melatonin (MT) has potential protective effect on cerebral ischemia-reperfusion injury (CIRI), but its underlying regulatory mechanism has not been identified.