Open Access<p>Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats</p>
Author(s) -
Taiyang Liao,
Liang Ding,
Peng Wu,
Li Zhang,
Xiaochen Li,
Bo Xu,
Haosheng Zhang,
Zhenyuan Ma,
Yancheng Xiao,
Peimin Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s261216
Subject(s) - chrysin , inflammation , inflammasome , medicine , osteoarthritis , pharmacology , synovial fluid , proinflammatory cytokine , immunology , chemistry , pathology , antioxidant , flavonoid , biochemistry , alternative medicine
Our recent reports have revealed that inhibiting NLRP3 activation reduces synovial inflammation and fibrosis in knee osteoarthritis (KOA). Synovial inflammation is involved the entire process of KOA and promotes the progression of KOA. Natural flavonoid Chrysin from Scutellariae Radix, a traditional Chinese medicine, exhibits multifarious biological activities and potentially has protective activity against osteoarthritis. However, the mechanism of Chrysin in the treatment of synovial inflammation remains elusive. The purpose of our research was to explore the anti-inflammatory effects of Chrysin on KOA, which was induced by monoiodoacetic acid (MIA) in rats by targeting the NLRP3 inflammasome in the hopes of identifying an effective drug to treat KOA.