Open Access<p>Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer</p>
Author(s) -
Chen Yang,
Li Wang,
Shuang Luo,
Jun Hu,
Xing Huang,
Peiwen Li,
Yi Zhang,
Chao Wu,
Bole Tian
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s261017
Subject(s) - paclitaxel , moiety , pancreatic cancer , liposome , chemistry , cancer , cancer research , maximum tolerated dose , pharmacology , medicine , combinatorial chemistry , stereochemistry , biochemistry
Pancreatic cancer, or pancreatic duct adenocarcinoma (PDAC), remains one of the most lethal cancers and features insidious onset, highly aggressive behavior and early distant metastasis. The dense fibrotic stroma surrounding tumor cells is thought to be a shield to resist the permeation of chemotherapy drugs in the treatment of PDAC. Thus, we synthesized a pancreas-targeting paclitaxel-loaded PEGylated liposome and investigated its antitumor efficacy in the patient-derived orthotopic xenograft (PDOX) nude mouse models of PDAC.