Open Access<p>Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats</p>
Author(s) -
KokYong Chin,
Benjamin Ka Seng Thong,
Rhivaldy Faahim Kamalulloh,
Nur-Vaizura Mohamad,
Sok Kuan Wong,
Azlan Mohd Arlamsyah,
Rahma Triliana
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s260565
Subject(s) - calcium , pantoprazole , tocotrienol , endocrinology , medicine , vitamin e , chemistry , tocopherol , biochemistry , antioxidant , omeprazole
Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims to compare the effects of calcium alone and in combination with annatto tocotrienol or vitamin D 3 (Caltrate Plus) in preventing bone loss caused by pantoprazole.