Open Access<p>Synthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates</p>
Author(s) -
Jiandang Shi,
Ping Wu,
Xiaoli Cheng,
Xiaoyi Wei,
ZiHua Jiang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s259547
Subject(s) - acetogenin , hela , chemistry , galactose , cytotoxicity , mtt assay , glycoconjugate , glycosyl , cell culture , biochemistry , stereochemistry , in vitro , annonaceae , biology , botany , genetics
Annonaceous acetogenins (ACGs) are secondary metabolites produced by the Annonaceae family and display potent anticancer activity against various cancer cell lines. Squamocin and bullatacin are two examples of ACGs that show promising antitumor activity; however, preclinical data are not sufficient partly due to their being highly lipophilic and poorly soluble in water. These compounds also display high toxicity to normal cells. Due to these disadvantageous properties, the therapeutic potential of squamocin and bullatacin as antitumor agents has not been fully evaluated.