Open Access<p>S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway</p>
Author(s) -
Guang Yang,
Shui Sun,
Jian Wang,
Wei Li,
Xianquan Wang,
Lin Yuan,
Siying Li
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s258973
Subject(s) - gene knockdown , oxidative stress , inflammation , chemistry , in vivo , pharmacology , cancer research , microbiology and biotechnology , biology , immunology , apoptosis , biochemistry
This study aimed to explore the potential role and mechanism of garlic-derived S-allylmercaptocysteine (SAMC), the major water-soluble fraction of garlic, in osteoarthritis (OA) both in vivo and in vitro.