Open Access<p>Osteogenic Effect of tsRNA-10277-Loaded Exosome Derived from Bone Mesenchymal Stem Cells on Steroid-Induced Osteonecrosis of the Femoral Head</p>
Author(s) -
Shanhong Fang,
Tianmin He,
Jiarun Jiang,
Yongfeng Li,
Peng Chen
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s258024
Subject(s) - mesenchymal stem cell , adipogenesis , wnt signaling pathway , chemistry , exosome , stem cell , microbiology and biotechnology , cellular differentiation , microvesicles , biology , microrna , signal transduction , biochemistry , gene
Steroids are known to inhibit osteogenic differentiation and subsequent bone formation in bone mesenchymal stem cells (BMSCs). However, little is known about the role of BMSC exosomes (Exos) and tRNA-derived small RNAs (tsRNAs) in steroid-induced osteonecrosis of the femoral head (SONFH). The objective of this study was to characterize the tsRNA expression profiles of plasma Exos collected from SONFH patients and healthy individuals using small RNA sequencing and further explore the effect of BMSC Exos carrying specific tsRNAs on osteogenic differentiation.