Open Access<p>Pharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS</p>
Author(s) -
Haozhen Zheng,
Xiao Shen,
Yingying He,
Xiangli Yan,
Shengxin Wang,
Aiming Yu,
Lisheng Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s257020
Subject(s) - paeoniflorin , calycosin , cmax , microdialysis , medicine , pharmacology , pharmacokinetics , high performance liquid chromatography , decoction , anesthesia , chemistry , chromatography , central nervous system , daidzein , formononetin , genistein
The aim of our research was to analyze and compare the pharmacokinetics of paeoniflorin, calycosin, calycosin-7-o-β-d-6-glucoside, and 6-gingerol in the blood and brain tissue of normal and cerebral ischemia-reperfusion injury rats by HPLC-MS/MS method.