Open Access<p>Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats</p>
Author(s) -
Qishan Wang,
Bei Xu,
Kai-Jian Fan,
YunWu Li,
Jing Wu,
Ting-Yu Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s256850
Subject(s) - dexamethasone , medicine , inflammation , arthritis , prostaglandin e2 , rheumatoid arthritis , joint pain , threshold of pain , pharmacology , prostaglandin , prostaglandin e , endocrinology , anesthesia
To overcome negative adverse effects and improve therapeutic index of dexamethasone (Dex) in rheumatoid arthritis (RA), we developed a novel sustained release formulation-intra-articular injectable dexamethasone-loaded thermosensitive hydrogel (DLTH) with chitosan-glycerin-borax as carrier for the remission of inflammation and pain. The focus of this article is to explore both anti-inflammatory and pain-relieving effects of DLTH joint injection in bovine type-II collagen-induced arthritis (CIA) rats.