Open Access<p>Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers</p>
Author(s) -
Bei-Bei He,
Nanbo Zheng,
Zhuanting Li,
Zhi Yuan
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s256636
Subject(s) - nanocarriers , in vivo , cancer , drug delivery , chemistry , cancer cell , colorectal cancer , pharmacology , combination therapy , polyethylene glycol , cancer research , biochemistry , drug , biology , medicine , microbiology and biotechnology , organic chemistry
Colorectal cancer (CRC) is the third most frequently diagnosed cancer and the fourth leading cause of cancer death over the world. Nano-sized drug delivery systems are used for the treatment of cancers. The aim of this study was to develop a tangeretin (TAGE) and atorvastatin (ATST) combined nano-system decorated with RGD (RGD-ATST/TAGE CNPs) for colon cancer combination therapy.