Open Access<p>Investigation of Inhibition Effect of Gossypol-Acetic Acid on Gastric Cancer Cells Based on a Network Pharmacology Approach and Experimental Validation</p>
Author(s) -
Youqiang Liu,
Yanlin Ma,
Zheng Li,
Yang Yang,
Bin Yu,
Zhenya Zhang,
Guiying Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s256566
Subject(s) - kegg , cell cycle , apoptosis , pi3k/akt/mtor pathway , biology , cell cycle checkpoint , cancer , cell growth , cancer cell , signal transduction , bioinformatics , cancer research , computational biology , gene , microbiology and biotechnology , genetics , gene expression , gene ontology
Gastric cancer (GC) is one of the major public health problems worldwide with high morbidity and mortality. Nowadays, traditional medicine may hold promise for the treatment of cancers. Gossypol-acetic acid (GAA) is a male contraceptive agent that shows anti-tumor effects on multiple types of cancers. However, whether GAA would inhibit the progression of GC remained unclear.