Open Access<p>Atorvastatin Combined with Low-Dose Dexamethasone Treatment Protects Endothelial Function Impaired by Chronic Subdural Hematoma via the Transcription Factor KLF-2</p>
Author(s) -
Yueshan Fan,
Dong Wang,
Chenxu Rao,
Ying Li,
Hongtao Rong,
Zengguang Wang,
Jianning Zhang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s256050
Subject(s) - endothelial stem cell , dexamethasone , atorvastatin , cell adhesion molecule , medicine , vascular endothelial growth factor , western blot , pharmacology , immunology , chemistry , cancer research , biochemistry , in vitro , vegf receptors , gene
Our previous study showed that the combination therapy with atorvastatin and low-dose dexamethasone protected endothelial cell function in chronic subdural hematoma (CSDH) injury. In this study, we aimed to investigate the mechanism underlying the effects of this combination therapy on CSDH-induced cell dysfunction.