Open Access<p>Ulinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression</p>
Author(s) -
Jincheng Zhang,
Yingqi Zhang,
Lei Chen,
Zhi-Ren Rao,
Yeqing Sun
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s255158
Subject(s) - regeneration (biology) , ulinastatin , sciatic nerve , microrna , peripheral nerve , medicine , peripheral , sciatic nerve injury , peripheral nervous system , peripheral nerve injury , nerve growth factor , nerve injury , pharmacology , anesthesia , anatomy , endocrinology , microbiology and biotechnology , biology , central nervous system , receptor , gene , biochemistry
Peripheral nerve injury is characterized as a common clinical problem. Ulinastatin (UTI) is a serine protease inhibitor with many biological activities including anti-inflammatory and antioxidant effects. Nonetheless, it is unknown whether UTI has a protective effect on peripheral nerve injury.