Open Access<p>Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p</p>
Author(s) -
Qi He,
Bo Zhang,
Feng Hu,
Jianwen Long,
Quan Shi,
Xianming Pi,
Hongxiang Chen,
Jiawen Li
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s254466
Subject(s) - hacat , triptolide , interleukin 22 , cell growth , downregulation and upregulation , keratinocyte , cell , cancer research , chemistry , medicine , apoptosis , immunology , cytokine , in vitro , biochemistry , interleukin , gene
Evidence has been shown that triptolide was effective in the treatment of psoriasis; however, the mechanisms remain poorly understood. Thus, this study aimed to investigate the role of triptolide on the proliferation and differentiation of HaCaT cells which are treated with IL22 to mimic abnormal proliferation/differentiation in keratinocyte of psoriasis.