Open Access<p>Knockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting <em>Itchy E3 Ubiquitin Protein Ligase</em></p>
Author(s) -
Daliang Kong,
Rui Gu,
Chengtao Zhang,
Ruofeng Yin
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s253293
Subject(s) - downregulation and upregulation , apoptosis , gene knockdown , cell cycle , ubiquitin ligase , western blot , cell cycle checkpoint , ubiquitin , in vitro , flow cytometry , in vivo , cell growth , biology , microbiology and biotechnology , cancer research , gene , biochemistry , genetics
Circular RNAs (circRNAs) play an important role in the progression of intervertebral disc (IVD) degeneration (IVDD). Using bioinformatics analysis, we have found that the expression of circRNA hsa_circ_0059955 was significantly downregulated in IVDD tissues. However, the relevant mechanism of hsa_circ_0059955 in the progression of IVDD remains unclear.