Open Access<p>Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling</p>
Author(s) -
Jing Wang,
Guangxiao Ni,
Yanming Liu,
Ying Han,
Lin Jia,
Yali Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s253280
Subject(s) - rhoa , neuroprotection , ischemia , axon , pharmacology , blot , staining , signal transduction , regeneration (biology) , microbiology and biotechnology , western blot , cerebral infarction , brain ischemia , chemistry , neuroscience , biology , medicine , pathology , biochemistry , gene
The aim of this study was to evaluate the neuroprotective effect of tanshinone IIA (TSA) on focal cerebral ischemia in rats and to investigate whether it was associated with Nogo-A/NgR1/RhoA/Rho-associated protein kinase 2 (ROCKII)/myosin light chain (MLC) signaling.